Valparaiso to Fuerte Amador (Panama City)

Characterful, colourful and a little chaotic, the port city of Valparaíso enjoys a somewhat awkward setting, scattered across 45 vertiginous hills. Thanks to this difficult topography the city streets are punctuated by steep staircases and funicular elevators, and energetic explorers will be rewarded with wonderful views of the pastel hued buildings that hug the slopes. Valparaíso's most famous former resident was the great Chilean poet Pablo Neruda, and you can visit one of his former residences, La Sebastiana, which now houses a small museum.

The busy port of Coquimbo is the gateway to the charming colonial city of La Serena, one of the oldest in Chile, where you’ll find attractive architecture and a fine stretch of beach. Other nearby sights include the fertile Elqui and Limarí Valleys, home to excellent wineries and ancient petroglyphs.

Situated in the far north of Chile, the golden sands of Iquique attract both sunseekers and thrillseekers; surfing and paragliding are particularly popular here thanks to the clear skies and the wind coming in off the Pacific. The city is also home to some charming old mansions, remnants of a 19th century nitrate mining boom.

Pisco is best known for its eponymous grape brandy, the key ingredient in a pisco sour cocktail. From here you can explore the desert landscapes of the Paracas Reserve, discover the rich marine life of the Ballestas Islands or fly over the mysterious Nazca Lines.

Peru’s underrated capital enjoys a fine setting on the Pacific coast, and the handsome colonial-era buildings surrounding the Plaza de Armas give clues to Lima’s distinguished history; for three centuries this was the capital of the Spanish Americas, when the city grew rich on the back of plundered Inca gold.

Salaverry is the nearest port to Trujillo, northern Peru’s most important city. Located amongst the verdant Andean foothills, Trujillo is home to a host of beautiful colonial buildings, and is also known for the spectacular nearby ruins of Chan Chan, the largest pre-Columbian city in South America.

Guayaquil is Ecuador’s largest city and most important commercial centre, and acts as the gateway to the Pacific coast and the wildlife haven of the Galapagos Islands. It’s a busy, buzzing sort of place, centred around the pleasant riverfront Malecón promenade.

The port of Fuerte Amador sits at the southern edge of Panama City, near the Pacific entrance to the Panama Canal. The shining skyscrapers of the Panamanian capital are a testament to the city’s status as a key financial centre, while the tiny Casco Viejo is home to pretty colonial streets, hip hotels and happening bars.