Civitavecchia (Rome) to Piraeus (Athens)

One of the world's great cities, Rome continues to dazzle and delight visitors with a potent mix of architectural marvels, continent-defining history and buzzing nightlife. As the saying goes, the city wasn't built in a day, and if you want to make the most of Rome you'll need to spend at least a couple of nights here. The Colosseum, the Vatican and the Forum are among the big ticket items, with the crowds to match, though in truth you will find history around almost every corner.

Salerno is the capital of the Campania region, an attractive city at the eastern end of the Amalfi Coast. The historic centre and beautiful seafront promenade are well worth exploring, and the ruins at nearby Paestum make for an interesting day trip.

Founded by Greek colonists in 734 BC, Siracusa was once the largest city in the ancient world, surpassing even Athens in its splendour. Highlights include the island of Ortigia, where narrow streets are lined by beautiful Baroque architecture, and the impressive ruins at the Parco Archeologico della Neapolis on the Sicilian mainland.

Malta’s tiny capital, established by the Knights of St John, packs in an awful lot of history considering its diminutive size. The atmospheric old streets, bathed in Mediterranean sunshine, are full of attractive honey-golden buildings, along with an impressive selection of bars and restaurants.

Nafplion is one of the most beautiful cities on the Greek mainland, situated on the Argolic Gulf overlooked by the imposing Palamidi Fortress. The narrow streets of the old town are home to a beguiling mix of Venetian, Turkish and Greek architecture, while just offshore is the little island castle of Bourtzi.

Athens is a city awash with historical and cultural significance, but it's much more than an open air museum; this is a dynamic, bustling metropolis, and a place where history is still very much unfolding.