22-Day Mediterranean Mosaic: Turkey, Greece, Italy & Spain

This is one of those destinations that really does live up to the hype! Istanbul is the place where East meets West, where Asia Minor reaches out across the Bosphorus and almost touches Europe. In its earlier incarnation as Constantinople, the city was the eastern bastion of the Byzantine Empire, holding out for centuries before finally capitulating to the Ottomans in 1453, and it remains a bristling, bustling cultural melting pot, the skyline dotted with magnificent minarets and domes.

Çanakkale occupies a key strategic location guarding the Dardanelles, at the meeting point of the Aegean and the Sea of Marmara. This region of Turkey is full of historical interest, including the battlefields of the disastrous Gallipoli campaign and the ruins of ancient Troy.

The bustling port of Volos sits on the site of the ancient city of Iolkos, the mythological home of Jason and the Argonauts. The modern city has plenty of interesting museums and churches, along with a pleasant waterfront lined with restaurants.

Saint John is said to have written the Book of Revelations in a cave on Patmos, and today the spot is marked by the hillside Monastery of the Apocalypse. As well as spirituality, the island is known for its beaches and upmarket vibe, with a scattering of stylish restaurants and bars.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

Athens is a city awash with historical and cultural significance, but it's much more than an open air museum; this is a dynamic, bustling metropolis, and a place where history is still very much unfolding.

Malta’s tiny capital, established by the Knights of St John, packs in an awful lot of history considering its diminutive size. The atmospheric old streets, bathed in Mediterranean sunshine, are full of attractive honey-golden buildings, along with an impressive selection of bars and restaurants.

Situated on the western edge of Sicily, closer to Tunis than it is to Rome, the historic port of Trapani has a discernible North African feel to it. This was once an important medieval trading centre that linked Carthage and Venice, and the lovely old town is a great place to spend some time exploring.

Sardinia’s capital is a fascinating patchwork of historical architecture and vertiginous streets, crowned by the old hilltop citadel of Il Castello. Explore the island’s history at the Museo Archeologico, where you can learn about Sardinia's ancient Nuragic civilisation.

The Sardinian city of Alghero is home to one of the loveliest old towns in the Mediterranean, with its cobbled lanes, elegant churches and golden sandstone architecture. The city was ruled for some 300 years by the Crown of Aragon and retains a uniquely Hispanic feel, with a dialect of Catalan still spoken by some locals.

Smaller than Mallorca and mellower than Ibiza, Menorca is rightly feted for its beautiful, unspoilt beaches. The laid back capital, Mahón, is set on the Mediterranean’s largest natural harbour, and the city’s striking Georgian architecture is a reminder of the 18th century British occupation of the island.

From the warren-like medieval streets of the Barri Gòtic to the fantastical modernist architecture of Antoni Gaudí, from the dizzy heights of Mount Tibidabo to the golden sands of Barceloneta, there’s never a dull moment in Barcelona.

Spain’s third city is a dazzling destination that combines historic architecture, cutting edge design and an inviting stretch of beach. Don’t miss the futuristic City of Arts and Sciences, designed by local architect Santiago Calatrava, or the old riverbed, now a delightful park.

Cartagena was founded by the Carthaginians around 227 BC, who named it after their home city in North Africa. These days the city is best known for its well-preserved Roman theatre, which was remarkably only discovered in 1987, in spite of its location in the centre of town.

The bustling port of Motril is less than an hour’s drive from Granada, last stronghold of the Moors in Spain and home to the famous Alhambra palace. The narrow streets of the Albayzín quarter are particularly evocative of the days of Al Andalus, and you can explore Granada’s Jewish heritage in the atmospheric Realejo district.

Melilla is a post-colonial oddity, a Spanish enclave on the north coast of Morocco. The city is a fascinating blend of Spanish, Moorish and Berber influences, with an impressive collection of modernist buildings, plenty of bustling tapas bars and an atmospheric walled old town, the Medina Sidonia.

The crumbling, sun-baked seafront city of Cádiz is said to be the oldest continuously inhabited settlement in the western world, founded by the Phoenicians around 1100 BC. Although the city lacks any obvious landmarks, it’s rich in atmosphere, and plays host to one of Spain’s most colourful carnivals.

Blessed with a dramatic setting on the steep banks of the river Douro, Portugal’s second city is currently enjoying something of a renaissance, and is best known as the home of the country’s most famous export, port wine.

Spread across steep hillsides that overlook the Rio Tejo, Lisbon’s colourful cityscape includes Gothic cathedrals, majestic monasteries and quaint museums. But for many the best times will be had wandering the narrow lanes of Lisbon’s lovely backstreets, with their great local food, wine and music.